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    mrpl4 mitochondrial ribosomal protein L4 [ Danio rerio (zebrafish) ]

    Gene ID: 553771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mrpl4provided by ZNC
    Official Full Name
    mitochondrial ribosomal protein L4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-388
    See related
    Ensembl:ENSDARG00000058824 AllianceGenome:ZFIN:ZDB-GENE-050522-388
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgmrpl4; zgc:110034; si:dkey-23f9.3
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL4 (mitochondrial ribosomal protein L4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mrpl4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (11319141..11331052, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (11335520..11347461, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4A1 Neighboring gene collagen, type IX, alpha 1a Neighboring gene HYLS1 centriolar and ciliogenesis associated Neighboring gene zgc:77929 Neighboring gene uncharacterized LOC137496640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial ribosomal protein mRpL4 regulates Notch signaling. Mo D, et al. EMBO Rep, 2023 Jun 5. PMID 37009823, Free PMC Article
    2. Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses. Kasai K, et al. Gene, 2013 Dec 1. PMID 23994290
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial ribosomal protein mRpL4 regulates Notch signaling.
      Title: The mitochondrial ribosomal protein mRpL4 regulates Notch signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110034

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL4m
    Names
    39S ribosomal protein L4, mitochondrial
    L4mt
    MRP-L4
    NP_001018572.1
    XP_005155804.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020736.1 → NP_001018572.1  large ribosomal subunit protein uL4m

      See identical proteins and their annotated locations for NP_001018572.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095145
      UniProtKB/Swiss-Prot
      Q503X2
      Related
      ENSDARP00000076204.4, ENSDART00000081765.6
      Conserved Domains (1) summary
      pfam00573
      Location:89 → 280
      Ribosomal_L4; Ribosomal protein L4/L1 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      11319141..11331052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155747.4 → XP_005155804.1  large ribosomal subunit protein uL4m isoform X1

      UniProtKB/TrEMBL
      A0A0R4ILL2, A0A8M2B2H8
      Related
      ENSDARP00000134997.1, ENSDART00000160247.2
      Conserved Domains (1) summary
      pfam00573
      Location:88 → 279
      Ribosomal_L4; Ribosomal protein L4/L1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q503X2.1 GenPept UniProtKB/Swiss-Prot:Q503X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.