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    clgn calmegin [ Danio rerio (zebrafish) ]

    Gene ID: 556495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clgnprovided by ZNC
    Official Full Name
    calmeginprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-708
    See related
    Ensembl:ENSDARG00000009315 AllianceGenome:ZFIN:ZDB-GENE-060929-708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    canx; fj49d10; wu:fj24b04; wu:fj49d10; zgc:153946
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in blood; central nervous system; and ventral mesoderm. Orthologous to human CLGN (calmegin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See clgn in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (40572757..40608366, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (39854684..39890485, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene mastermind-like transcriptional coactivator 3 Neighboring gene short coiled-coil protein a Neighboring gene N-alpha-acetyltransferase 15, NatA auxiliary subunit b Neighboring gene uncharacterized LOC137493459 Neighboring gene ras-related protein Rab-33B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076
    2. Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. Grimholt U. BMC Evol Biol, 2018 Feb 23. PMID 29471808, Free PMC Article
    3. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153946

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calmegin
    Names
    calnexin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077541.1 → NP_001071009.1  calmegin precursor

      See identical proteins and their annotated locations for NP_001071009.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124496
      UniProtKB/TrEMBL
      A0A8M1NAD5, Q08BY9
      Related
      ENSDARP00000092445.4, ENSDART00000101671.5
      Conserved Domains (1) summary
      pfam00262
      Location:72 → 441
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      40572757..40608366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160003.5 → XP_005160060.1  calmegin isoform X1

      UniProtKB/TrEMBL
      A0A8M2B772
      Conserved Domains (1) summary
      pfam00262
      Location:72 → 441
      Calreticulin; Calreticulin family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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