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    ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) [ Danio rerio (zebrafish) ]

    Gene ID: 406408, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddostprovided by ZNC
    Official Full Name
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2147
    See related
    Ensembl:ENSDARG00000037318 AllianceGenome:ZFIN:ZDB-GENE-040426-2147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66068; zgc:77478; wu:fa11d01
    Summary
    Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in axis; notochord; and polster. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ir. Orthologous to human DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ddost in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (24227296..24234287, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (24300745..24307736, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene anoctamin 11 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 2 Neighboring gene zinc finger and BTB domain containing 17 Neighboring gene heat shock protein family, member 7 (cardiovascular)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function. Xi Y, et al. Eur J Neurosci, 2010 Feb. PMID 20141529
    2. A central function for perlecan in skeletal muscle and cardiovascular development. Zoeller JJ, et al. J Cell Biol, 2008 Apr 21. PMID 18426981, Free PMC Article
    3. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Rawls JF, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070763, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation via asparagine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
    Names
    DDOST 48 kDa subunit
    dolichyl-diphosphooligosaccharide-protein glycosyltransferase
    oligosaccharyl transferase 48 kDa subunit
    NP_998258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213093.1 → NP_998258.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

      See identical proteins and their annotated locations for NP_998258.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066475
      UniProtKB/Swiss-Prot
      Q6NYS8, Q6PHG6
      UniProtKB/TrEMBL
      A0A0R4I9F5
      Related
      ENSDARP00000105892.2, ENSDART00000124539.3
      Conserved Domains (1) summary
      pfam03345
      Location:33 → 440
      DDOST_48kD; Oligosaccharyltransferase 48 kDa subunit beta

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      24227296..24234287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYS8.2 GenPept UniProtKB/Swiss-Prot:Q6NYS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.