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    shc1 SHC (Src homology 2 domain containing) transforming protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 323818, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shc1provided by ZNC
    Official Full Name
    SHC (Src homology 2 domain containing) transforming protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2538
    See related
    Ensembl:ENSDARG00000075437 AllianceGenome:ZFIN:ZDB-GENE-030131-2538
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc10h03; si:dkey-246i14.4
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within angiogenesis. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See shc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (22782010..22863395, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (22866624..22948043, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene pre-B-cell leukemia homeobox interacting protein 1b Neighboring gene lens epithelial protein Neighboring gene ephrin A4 Neighboring gene flavin adenine dinucleotide synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology. Haslem L, et al. J Cardiovasc Dev Dis, 2022 Nov 9. PMID 36354784, Free PMC Article
    2. The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis. Sweet DT, et al. Blood, 2012 Feb 23. PMID 22096252, Free PMC Article
    3. Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. Li L, et al. iScience, 2023 Apr 21. PMID 37009226, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      22782010..22863395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169756.5 → XP_005169813.1  SHC-transforming protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BH44, E9QCZ8
      Related
      ENSDARP00000123188.1, ENSDART00000147609.3
      Conserved Domains (2) summary
      cd09925
      Location:346 → 449
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:35 → 206
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    2. XM_005169755.5 → XP_005169812.1  SHC-transforming protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BH05, E7F3T0
      Related
      ENSDARP00000089171.4, ENSDART00000098400.5
      Conserved Domains (2) summary
      cd09925
      Location:351 → 454
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:40 → 211
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    3. XM_009292293.4 → XP_009290568.1  SHC-transforming protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AJ37
      Conserved Domains (2) summary
      cd09925
      Location:472 → 575
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:179 → 332
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    4. XM_017351494.3 → XP_017206983.1  SHC-transforming protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1Z9
    Nucleotide Protein Strain
    Heading Accession and Version

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