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    bcar1 BCAR1 scaffold protein, Cas family member [ Danio rerio (zebrafish) ]

    Gene ID: 568309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bcar1provided by ZNC
    Official Full Name
    BCAR1 scaffold protein, Cas family memberprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2774
    See related
    Ensembl:ENSDARG00000056525 AllianceGenome:ZFIN:ZDB-GENE-030131-2774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc17f11; wu:fc17f11; zgc:175192
    Summary
    Acts upstream of or within regulation of lymphangiogenesis and regulation of sprouting angiogenesis. Predicted to be located in anchoring junction. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bcar1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22503770..22688073)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (22514584..22699007)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170A Neighboring gene craniofacial development protein 1 Neighboring gene uncharacterized LOC137488279 Neighboring gene si:dkey-11d18.2 Neighboring gene nudix hydrolase 21 Neighboring gene heat shock transcription factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Wisniewski L, et al. Sci Rep, 2020 Sep 24. PMID 32973180, Free PMC Article
    2. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC175192

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    breast cancer anti-estrogen resistance protein 1
    Names
    BCAR1, Cas family scaffold protein
    breast cancer anti-estrogen resistance 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135133.2 → NP_001128605.1  breast cancer anti-estrogen resistance protein 1

      See identical proteins and their annotated locations for NP_001128605.1

      Status: VALIDATED

      Source sequence(s)
      BC168512, CR933017
      UniProtKB/TrEMBL
      A0A8M1NIP6, B5DE36
      Related
      ENSDARP00000106517.2, ENSDART00000128965.3
      Conserved Domains (3) summary
      cd12001
      Location:4 → 70
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam08824
      Location:488 → 643
      Serine_rich; Serine rich protein interaction domain
      pfam12026
      Location:705 → 913
      DUF3513; Domain of unknown function (DUF3513)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      22503770..22688073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467686.2 → XP_021323361.1  breast cancer anti-estrogen resistance protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM80
      Related
      ENSDARP00000144076.1, ENSDART00000176130.2
      Conserved Domains (5) summary
      cd11552
      Location:530 → 686
      Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
      cd12001
      Location:46 → 112
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam08703
      Location:764 → 815
      PLC-beta_C; PLC-beta C terminal
      cl13463
      Location:827 → 958
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
      cl27975
      Location:123 → 254
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    2. XM_005159138.5 → XP_005159195.1  breast cancer anti-estrogen resistance protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A2R8Q9D0, A0A8M2B621
      Related
      ENSDARP00000147960.1, ENSDART00000184472.1
      Conserved Domains (3) summary
      cd12001
      Location:31 → 97
      SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
      pfam08824
      Location:515 → 670
      Serine_rich; Serine rich protein interaction domain
      pfam12026
      Location:732 → 940
      DUF3513; Domain of unknown function (DUF3513)

    3. XM_005159139.5 → XP_005159196.1  breast cancer anti-estrogen resistance protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8QJQ5, A0A8M2B5Q8
      Related
      ENSDARP00000152559.1, ENSDART00000192281.1
      Conserved Domains (3) summary
      pfam08824
      Location:488 → 643
      Serine_rich; Serine rich protein interaction domain
      pfam12026
      Location:705 → 913
      DUF3513; Domain of unknown function (DUF3513)
      cl17036
      Location:5 → 70
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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