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    ube2r2 ubiquitin-conjugating enzyme E2R 2 [ Danio rerio (zebrafish) ]

    Gene ID: 436873, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ube2r2provided by ZNC
    Official Full Name
    ubiquitin-conjugating enzyme E2R 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-344
    See related
    Ensembl:ENSDARG00000058740 AllianceGenome:ZFIN:ZDB-GENE-040718-344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92307
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Orthologous to human UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ube2r2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11842764..11856143, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11750140..11763514, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene Rieske (Fe-S) domain containing Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 2 Neighboring gene uncharacterized LOC137488785 Neighboring gene ubiquitin associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 R2
    NP_001002600.1
    XP_005161075.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002600.1 → NP_001002600.1  ubiquitin-conjugating enzyme E2 R2

      See identical proteins and their annotated locations for NP_001002600.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075995
      UniProtKB/TrEMBL
      A0A8M1N0S7, Q6DHH9
      Related
      ENSDARP00000076107.3, ENSDART00000081666.5
      Conserved Domains (2) summary
      COG5078
      Location:7 → 169
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:11 → 169
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      11842764..11856143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161018.5 → XP_005161075.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

      See identical proteins and their annotated locations for XP_005161075.1

      UniProtKB/TrEMBL
      A0A8M1N0S7, Q6DHH9
      Related
      ENSDARP00000126174.1, ENSDART00000151204.2
      Conserved Domains (2) summary
      COG5078
      Location:7 → 169
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:11 → 169
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version

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