gdap1 ganglioside induced differentiation associated protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gdap1provided by ZNC
Official Full Name: ganglioside induced differentiation associated protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-424
See related: Ensembl:ENSDARG00000058601 AllianceGenome:ZFIN:ZDB-GENE-050522-424
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112286; si:rp71-1m12.2
Summary: Acts upstream of or within neuron projection development. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in central nervous system and cranial ganglion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease axonal type 2K; Charcot-Marie-Tooth disease recessive intermediate A; and Charcot-Marie-Tooth disease type 4A. Orthologous to human GDAP1 (ganglioside induced differentiation associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (14711430..14725774)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (14567048..14581355)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that GDAP1 knockdown affects sensory neurite development, however, it is unclear if a problem in mitochondrial fission and network formation is the pathophysiological mechanism.
Title: A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ganglioside-induced differentiation-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020675.1 → NP_001018511.1 ganglioside-induced differentiation-associated protein 1

See identical proteins and their annotated locations for NP_001018511.1

Status: PROVISIONAL

Source sequence(s)

BC095731

UniProtKB/TrEMBL

Q78AN2

Related

ENSDARP00000113431.1, ENSDART00000134475.2

Conserved Domains (3) summary

COG0625
Location:40 → 307

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03052
Location:40 → 112

GST_N_GDAP1; GST_N family, Ganglioside-induced differentiation-associated protein 1 (GDAP1) subfamily; GDAP1 was originally identified as a highly expressed gene at the differentiated stage of GD3 synthase-transfected cells. More recently, mutations in GDAP1 have ...

cl02776
Location:193 → 304

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

14711430..14725774

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162643.4 → XP_005162700.1 ganglioside-induced differentiation-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B9N6

Conserved Domains (3) summary

cd10303
Location:111 → 222

GST_C_GDAP1; C-terminal, alpha helical domain of Ganglioside-induced differentiation-associated protein 1

COG0625
Location:1 → 225

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cl00388
Location:1 → 30

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold