egr4 early growth response 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: egr4provided by ZNC
Official Full Name: early growth response 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-080204-90
See related: Ensembl:ENSDARG00000077799 AllianceGenome:ZFIN:ZDB-GENE-080204-90
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:175128
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain. Used to study congenital heart disease. Orthologous to human EGR4 (early growth response 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (45579504..45581626)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (45844309..45846431)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: early growth response protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114453.1 → NP_001107925.1 early growth response protein 4

See identical proteins and their annotated locations for NP_001107925.1

Status: PREDICTED

Source sequence(s)

BC155326

UniProtKB/TrEMBL

A0A8M1NFL1, A9JTG0

Related

ENSDARP00000102334.2, ENSDART00000110381.3

Conserved Domains (3) summary

COG5048
Location:278 → 344

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:252 → 274

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:294 → 319

zf-H2C2_2; Zinc-finger double domain