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    tdrd6a tudor domain containing 6a [ Danio rerio (zebrafish) ]

    Gene ID: 565665, updated on 15-Dec-2024

    Summary

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    Official Symbol
    tdrd6aprovided by ZNC
    Official Full Name
    tudor domain containing 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-210
    See related
    Ensembl:ENSDARG00000070052 AllianceGenome:ZFIN:ZDB-GENE-041001-210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tdrd6; si:dkey-30j22.9
    Summary
    Involved in P granule assembly; regulation of oogenesis; and spermatogenesis. Located in P granule and chromatoid body. Is active in germ plasm and mitochondrial cloud. Orthologous to human TDRD6 (tudor domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tdrd6a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (35438392..35462213)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35535420..35559334)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene visinin-like 1a Neighboring gene splicing factor 3b, subunit 6 Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Neighboring gene meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1 Neighboring gene meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2 Neighboring gene adhesion G protein-coupled receptor F3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification. Roovers EF, et al. Dev Cell, 2018 Aug 6. PMID 30086300, Free PMC Article
    2. Comparative studies on duplicated tdrd7 paralogs in teleosts: Molecular evolution caused neo-functionalization. Wang B, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2019 Jun. PMID 31059868
    3. Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. Valcarce DG, et al. BMC Biol, 2023 Apr 3. PMID 37013516, Free PMC Article
    4. Exploring uncoupling proteins and antioxidant mechanisms under acute cold exposure in brains of fish. Tseng YC, et al. PLoS One, 2011 Mar 25. PMID 21464954, Free PMC Article
    5. Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Wang X, et al. Nat Commun, 2023 Dec 14. PMID 38097571, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in germ cell development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatoid body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in germ plasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in mitochondrial cloud IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tudor domain-containing 6
    Names
    tudor domain containing 6
    tudor domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423790.1 → NP_001410719.1  tudor domain-containing 6

      Status: VALIDATED

      Source sequence(s)
      BX510920, CK870521, EB910631, EB911109, EB916560, EE701388
      UniProtKB/Swiss-Prot
      F1R237, F1RE34
      Related
      ENSDARP00000093281.2, ENSDART00000102504.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      35438392..35462213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011007691.1 RNA Sequence

    2. XR_011007692.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1R237.2 GenPept UniProtKB/Swiss-Prot:F1R237

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.