hoxa13b homeobox A13b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hoxa13bprovided by ZNC
Official Full Name: homeobox A13bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-365
See related: Ensembl:ENSDARG00000036254 AllianceGenome:ZFIN:ZDB-GENE-980526-365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: HOXA13; Hoxa-13; wu:fa66g07; zgc:110514
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within fin development and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including chondroblast; mesoderm; oocyte; pectoral fin; and tail bud. Human ortholog(s) of this gene implicated in Guttmacher syndrome and hand-foot-genital syndrome. Orthologous to human HOXA13 (homeobox A13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (20895904..20897833)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (21090085..21092014)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression.
Title: Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression.
Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development.
Title: Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development.

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General gene information

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Markers

aa658751 (e-PCR)
- UniSTS:186924

fa66g07 (e-PCR)
- UniSTS:188848

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Hox-A13b

Names: homeo box A13b; homeobox gene A-13b; hox-A13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.