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    mtdha metadherin a [ Danio rerio (zebrafish) ]

    Gene ID: 368910, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mtdhaprovided by ZNC
    Official Full Name
    metadherin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-615
    See related
    Ensembl:ENSDARG00000014159 AllianceGenome:ZFIN:ZDB-GENE-030616-615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lyric; lyricl; wu:fc33g06; si:zc215i13.6
    Summary
    Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtdha in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (32895379..32914231, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (33308259..33327180, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30 Neighboring gene lysosomal protein transmembrane 4 beta Neighboring gene ribonucleotide reductase M2 b Neighboring gene antizyme inhibitor 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    2. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
    3. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    metadherin a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007135.2 → NP_001007136.2  metadherin a

      See identical proteins and their annotated locations for NP_001007136.2

      Status: PROVISIONAL

      Source sequence(s)
      BC068430
      UniProtKB/TrEMBL
      Q6NUU0
      Related
      ENSDARP00000147602.1, ENSDART00000186115.1
      Conserved Domains (1) summary
      pfam15686
      Location:5 → 445
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      32895379..32914231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159603.4 → XP_005159660.1  metadherin a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B6D6, A8DZ70, E7EZ81
      Related
      ENSDARP00000111658.2, ENSDART00000124246.4
      Conserved Domains (1) summary
      pfam15686
      Location:5 → 446
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family

    2. XM_005159604.4 → XP_005159661.1  metadherin a isoform X3

      UniProtKB/TrEMBL
      A0A2R8QJH1, A0A8M2B6A1
      Conserved Domains (1) summary
      pfam15686
      Location:5 → 446
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family

    3. XM_017352195.3 → XP_017207684.1  metadherin a isoform X1

      UniProtKB/TrEMBL
      A0A8M6YWB0

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395056.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      32029..50877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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