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    • Showing Current items.

    zgc:114200 zgc:114200 [ Danio rerio (zebrafish) ]

    Gene ID: 559336, updated on 9-Dec-2024

    Summary

    Official Symbol
    zgc:114200provided by ZNC
    Official Full Name
    zgc:114200provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-96
    See related
    Ensembl:ENSDARG00000100633 AllianceGenome:ZFIN:ZDB-GENE-050913-96
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to act upstream of or within positive regulation of catalytic activity. Predicted to be located in membrane. Predicted to be part of gamma-secretase complex. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See zgc:114200 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (6383286..6400753)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (6382077..6399544)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene talin 1 Neighboring gene tropomyosin 2 (beta) Neighboring gene carbonic anhydrase IX Neighboring gene decapping mRNA 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC114200

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of gamma-secretase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Gamma-secretase subunit Aph-1b-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030129.2NP_001025300.1  Gamma-secretase subunit Aph-1b-like

      See identical proteins and their annotated locations for NP_001025300.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097248
      UniProtKB/TrEMBL
      Q4V8Q7
      Related
      ENSDARP00000133858.1, ENSDART00000170548.2
      Conserved Domains (1) summary
      pfam06105
      Location:2233
      Aph-1; Aph-1 protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      6383286..6400753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)