U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    zbtb4 zinc finger and BTB domain containing 4 [ Danio rerio (zebrafish) ]

    Gene ID: 798710, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    zbtb4provided by ZNC
    Official Full Name
    zinc finger and BTB domain containing 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100318-5
    See related
    Ensembl:ENSDARG00000105255 AllianceGenome:ZFIN:ZDB-GENE-100318-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kzp
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within convergent extension involved in gastrulation; regionalization; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in eye; forebrain; head; and midbrain hindbrain boundary. Orthologous to human ZBTB4 (zinc finger and BTB domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See zbtb4 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (22528748..22540980, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (22407531..22419898, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene sex hormone-binding globulin Neighboring gene RNA polymerase II subunit A Neighboring gene capping protein (actin filament), gelsolin-like b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs. Narayanan A, et al. Dev Dyn, 2012 Jun. PMID 22473868
    2. Kzp regulates the transcription of gata2 and pu.1 during primitive hematopoiesis in zebrafish embryos. Liu F, et al. J Genet Genomics, 2012 Sep 20. PMID 23021546
    3. Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. Yao S, et al. J Biol Chem, 2010 Dec 31. PMID 20978132, Free PMC Article
    4. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation
      Title: Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal convergence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mediolateral intercalation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger and BTB domain-containing protein 38
    Names
    KAISO-like zinc finger protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      22528748..22540980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001339110.7 → XP_001339146.2  zinc finger and BTB domain-containing protein 38

      UniProtKB/TrEMBL
      A0A0R4INF0, A0A8M1Q7E8
      Related
      ENSDARP00000137838.1, ENSDART00000172310.2
      Conserved Domains (2) summary
      PTZ00121
      Location:630 → 946
      PTZ00121; MAEBL; Provisional
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools