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    gsr glutathione reductase [ Danio rerio (zebrafish) ]

    Gene ID: 553575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gsrprovided by ZNC
    Official Full Name
    glutathione reductaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-116
    See related
    Ensembl:ENSDARG00000019236 AllianceGenome:ZFIN:ZDB-GENE-050522-116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110010
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity and glutathione-disulfide reductase (NADPH) activity. Acts upstream of or within cell redox homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in intestinal bulb; liver; and macrophage. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gsr in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (38852969..38873095, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (38512655..38532821, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A0b Neighboring gene heterogeneous nuclear ribonucleoprotein A0, like Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene translocase of inner mitochondrial membrane 8 homolog A (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sodium benzoate induced developmental defects, oxidative stress and anxiety-like behaviour in zebrafish larva. Gaur H, et al. Biochem Biophys Res Commun, 2018 Jul 20. PMID 29842881
    2. Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle. Haridevamuthu B, et al. Life Sci, 2022 Jun 1. PMID 35358593
    3. Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models. Poon KL, et al. Toxicol Sci, 2017 Mar 1. PMID 28069987
    4. In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy. Díaz-Casado ME, et al. Zebrafish, 2018 Feb. PMID 29185873
    5. Hepatic gene expression profiling in zebrafish (Danio rerio) exposed to the fungicide chlorothalonil. Sánchez Garayzar AB, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27264782

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC110010

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione reductase, mitochondrial
    NP_001018390.1
    XP_005169649.1
    XP_017214504.1
    XP_021336698.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020554.1 → NP_001018390.1  glutathione reductase, mitochondrial

      See identical proteins and their annotated locations for NP_001018390.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095128
      UniProtKB/TrEMBL
      Q503Y5
      Related
      ENSDARP00000047049.6, ENSDART00000047050.8
      Conserved Domains (3) summary
      TIGR01421
      Location:25 → 425
      gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
      pfam00070
      Location:177 → 253
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:313 → 423
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      38852969..38873095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481023.2 → XP_021336698.1  glutathione reductase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M9QB21
      Conserved Domains (1) summary
      cl27343
      Location:25 → 469
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

    2. XM_005169592.5 → XP_005169649.1  glutathione reductase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2M1, E7FGA5
      Conserved Domains (3) summary
      TIGR01421
      Location:56 → 500
      gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
      pfam00070
      Location:208 → 284
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:390 → 498
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    3. XM_017359015.3 → XP_017214504.1  glutathione reductase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2M1, E7FGA5
      Related
      ENSDARP00000108870.1, ENSDART00000127479.3
      Conserved Domains (3) summary
      TIGR01421
      Location:56 → 500
      gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
      pfam00070
      Location:208 → 284
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:390 → 498
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394925.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      118307..139720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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