mad2l2 mitotic arrest deficient 2 like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mad2l2provided by ZNC
Official Full Name: mitotic arrest deficient 2 like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-61
See related: Ensembl:ENSDARG00000042456 AllianceGenome:ZFIN:ZDB-GENE-050417-61
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110299; si:dkey-23c22.2
Summary: Predicted to be involved in DNA damage response, signal transduction resulting in transcription; positive regulation of DNA-templated transcription; and regulation of protein metabolic process. Predicted to act upstream of or within DNA damage response and cell division. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex and zeta DNA polymerase complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (22345285..22348391)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (22324038..22327153)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction resulting in transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
part_of zeta DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of zeta DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitotic spindle assembly checkpoint protein MAD2B

Names: MAD2-like protein 2; mitotic arrest deficient 2-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.