parla presenilin associated, rhomboid-like a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: parlaprovided by ZNC
Official Full Name: presenilin associated, rhomboid-like aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050327-8
See related: Ensembl:ENSDARG00000039310 AllianceGenome:ZFIN:ZDB-GENE-050327-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: parl; zgc:112986
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in mitochondrial inner membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (5543898..5561019, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (5631910..5649141, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.
Title: Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: presenilin-associated rhomboid-like protein A, mitochondrial

Names: parlb; presenilins-associated rhomboid-like protein, mitochondrial

NP_001014320.1

EC 3.4.21.105

XP_068080083.1

EC 3.4.21.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.