eya1 EYA transcriptional coactivator and phosphatase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eya1provided by ZNC
Official Full Name: EYA transcriptional coactivator and phosphatase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990712-18
See related: Ensembl:ENSDARG00000014259 AllianceGenome:ZFIN:ZDB-GENE-990712-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc13c10; zgc:100770
Summary: Predicted to enable metal ion binding activity and protein tyrosine phosphatase activity. Acts upstream of or within adenohypophysis development; otic vesicle morphogenesis; and otolith development. Predicted to be located in nucleus. Is expressed in several structures, including adenohypophyseal placode; ectoderm; head; mesoderm pectoral fin bud; and nervous system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and branchiootorenal syndrome 1. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (13925081..14015458)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (13780648..13871039)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of miR-124-3p affects zebrafish inner ear development and hearing function via downregulation of EYA1 gene expression.
Title: Overexpression of miR-124-3p affects zebrafish inner ear development and hearing function via downregulation of EYA1 gene expression.
Data report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1) as novel interaction partners of Eya1.
Title: Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
First report of an essential role of Eya1, which is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival.
Title: Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenohypophysis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adenohypophysis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic vesicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eyes absent homolog 1

Names: dog eared

NP_571268.1

EC 3.1.3.48

XP_005162690.1

EC 3.1.3.48

XP_005162691.1

EC 3.1.3.48

XP_005162692.1

EC 3.1.3.48

XP_009295600.2

EC 3.1.3.48

XP_009295601.2

EC 3.1.3.48

XP_009295602.1

EC 3.1.3.48

XP_017209289.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.