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    klc1b kinesin light chain 1b [ Danio rerio (zebrafish) ]

    Gene ID: 335499, updated on 4-Jan-2025

    Summary

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    Official Symbol
    klc1bprovided by ZNC
    Official Full Name
    kinesin light chain 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7439
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-7439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Klc2; klc1; kns2; zgc:55666; zgc:77660; wu:fj17e04
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See klc1b in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (51903588..52169179)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (51518774..51530158)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene zmp:0000000755 Neighboring gene LBH regulator of WNT signaling pathway Neighboring gene serum response factor b Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene protein tyrosine kinase 7b Neighboring gene solute carrier family 30 member 10 Neighboring gene lysocardiolipin acyltransferase 1 Neighboring gene kelch domain containing 3 Neighboring gene transmembrane protein 121 Neighboring gene neuronal PAS domain protein 4 like Neighboring gene uncharacterized LOC100331665 Neighboring gene L-threonine ammonia-lyase-like Neighboring gene serine/threonine-protein kinase 32C Neighboring gene uncharacterized LOC100535731 Neighboring gene transmembrane protein 254 Neighboring gene fibrillin-1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2. Li S, et al. Dev Neurobiol, 2024 Jul. PMID 38830696
    2. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Reischauer S, et al. Nature, 2016 Jul 14. PMID 27411634
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2.
      Title: Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55666

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain 1b
    Names
    kinesin 2
    kinesin light chain 1
    kinesin light chain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199954.1 → NP_956248.1  kinesin light chain 1b

      See identical proteins and their annotated locations for NP_956248.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063959
      UniProtKB/TrEMBL
      Q6P3K1, Q7ZVT4
      Conserved Domains (4) summary
      sd00006
      Location:294 → 322
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:293 → 334
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:248 → 326
      TPR_12; Tetratricopeptide repeat
      cl00388
      Location:13 → 70
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      51903588..52169179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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