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    plekhg6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [ Danio rerio (zebrafish) ]

    Gene ID: 563725, updated on 27-Dec-2024

    Summary

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    Official Symbol
    plekhg6provided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2517
    See related
    Ensembl:ENSDARG00000086056 AllianceGenome:ZFIN:ZDB-GENE-030131-2517
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc10d07; wu:fc10d07; si:ch211-215m13.2
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plekhg6 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17007089..17056561, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17099114..17148685, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-120k19.1 Neighboring gene ribosomal protein L18 Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene uncharacterized LOC137487920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Cao M, et al. Dev Comp Immunol, 2022 Jul. PMID 35364135
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      17007089..17056561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292202.4 → XP_009290477.1  pleckstrin homology domain-containing family G member 6 isoform X2

      UniProtKB/TrEMBL
      A0A140LH23, A0A8M3AQG8
      Related
      ENSDARP00000142553.1, ENSDART00000138715.3
      Conserved Domains (3) summary
      pfam00169
      Location:421 → 515
      PH; PH domain
      pfam00621
      Location:176 → 363
      RhoGEF; RhoGEF domain
      cl17171
      Location:418 → 514
      PH-like; Pleckstrin homology-like domain

    2. XM_009292201.4 → XP_009290476.1  pleckstrin homology domain-containing family G member 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATA9
      Conserved Domains (3) summary
      pfam00169
      Location:421 → 515
      PH; PH domain
      pfam00621
      Location:176 → 363
      RhoGEF; RhoGEF domain
      cl17171
      Location:418 → 514
      PH-like; Pleckstrin homology-like domain

    3. XM_009292203.4 → XP_009290478.1  pleckstrin homology domain-containing family G member 6 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AHZ2
      Conserved Domains (3) summary
      pfam00169
      Location:421 → 515
      PH; PH domain
      pfam00621
      Location:176 → 363
      RhoGEF; RhoGEF domain
      cl17171
      Location:418 → 514
      PH-like; Pleckstrin homology-like domain

    4. XM_068214108.1 → XP_068070209.1  pleckstrin homology domain-containing family G member 6 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AHZ2
    Nucleotide Protein Strain
    Heading Accession and Version

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