trabd2a TraB domain containing 2A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trabd2aprovided by ZNC
Official Full Name: TraB domain containing 2Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4053
See related: Ensembl:ENSDARG00000089701 AllianceGenome:ZFIN:ZDB-GENE-030131-4053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TIKI1; fc66h01; wu:fc66h01
Summary: Predicted to enable Wnt-protein binding activity and metalloendopeptidase activity. Predicted to be involved in head development and negative regulation of Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be located in organelle membrane and plasma membrane. Predicted to be active in membrane. Orthologous to human TRABD2A (TraB domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (249939..299588)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (199186..248562, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G40178 (e-PCR)
- UniSTS:32045

fc66h01.x1 (e-PCR)
- UniSTS:204003

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt-protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in head development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metalloprotease TIKI1

Names: TRAB domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.