ubxn1 UBX domain protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ubxn1provided by ZNC
Official Full Name: UBX domain protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-792
See related: Ensembl:ENSDARG00000090309 AllianceGenome:ZFIN:ZDB-GENE-030131-792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb49a05; zgc:77531; wu:fb49a05
Summary: Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and K6-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; and negative regulation of protein ubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (45471736..45482605)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (46484417..46495313)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI477917 (e-PCR)
- UniSTS:206432

fb49a05.x1 (e-PCR)
- UniSTS:190607

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K6-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein K48-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UBX domain-containing protein 1

Names: SAPK substrate protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212607.1 → NP_997772.1 UBX domain-containing protein 1

See identical proteins and their annotated locations for NP_997772.1

Status: PROVISIONAL

Source sequence(s)

BC067166

UniProtKB/Swiss-Prot

Q6NXA9

UniProtKB/TrEMBL

A0A8M6Z444

Related

ENSDARP00000108064.1, ENSDART00000126979.4

Conserved Domains (2) summary

cd01772
Location:215 → 293

SAKS1_UBX; SAKS1-like UBX domain

cd14302
Location:5 → 45

UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins