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    asns asparagine synthetase [ Danio rerio (zebrafish) ]

    Gene ID: 394138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asnsprovided by ZNC
    Official Full Name
    asparagine synthetaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1091
    See related
    Ensembl:ENSDARG00000016375 AllianceGenome:ZFIN:ZDB-GENE-040426-1091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56605; zgc:76901
    Summary
    Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process and glutamine metabolic process. Predicted to be active in cytosol. Is expressed in liver; male organism; and muscle. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See asns in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (25654361..25677992, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (26070138..26093769, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex assembly factor 3 Neighboring gene tachykinin precursor 1 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino Neighboring gene par-6 family cell polarity regulator gamma b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo. Waldron A, et al. Front Cell Dev Biol, 2019. PMID 31134197, Free PMC Article
    2. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Mirando AC, et al. Sci Rep, 2015 Aug 14. PMID 26271225, Free PMC Article
    3. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Zhang F, et al. Cell Discov, 2021 Oct 26. PMID 34697290, Free PMC Article
    4. Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Ding Q, et al. Front Nutr, 2022. PMID 35685883, Free PMC Article
    5. Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Ruggiero G, et al. Front Mol Neurosci, 2021. PMID 34539343, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56605

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asparagine synthetase [glutamine-hydrolyzing]
    NP_957457.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201163.3 → NP_957457.3  asparagine synthetase [glutamine-hydrolyzing]

      Status: VALIDATED

      Source sequence(s)
      BX842688
      UniProtKB/TrEMBL
      A0A8N1Z345, A3KQK2
      Related
      ENSDARP00000107713.2, ENSDART00000121476.3
      Conserved Domains (3) summary
      PRK09431
      Location:1 → 554
      asnB; asparagine synthetase B; Provisional
      cd00712
      Location:2 → 189
      AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
      pfam00733
      Location:234 → 532
      Asn_synthase; Asparagine synthase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      25654361..25677992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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