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    st6gal1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    st6gal1provided by ZNC
    Official Full Name
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060322-3
    See related
    Ensembl:ENSDARG00000044514 AllianceGenome:ZFIN:ZDB-GENE-060322-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    siat1; zgc:136454
    Summary
    Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to be involved in sialylation. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in gill; liver; nervous system; and pleuroperitoneal region. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See st6gal1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (31151110..31185301)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (31113743..31149968)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene transfer RNA valine (anticodon UAC) Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA aspartic acid (anticodon GUC) Neighboring gene transfer RNA aspartic acid (anticodon GUC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. Petit D, et al. J Biol Chem, 2010 Dec 3. PMID 20855889, Free PMC Article
    2. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
    3. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
    4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC136454

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 1
    Names
    beta-galactoside alpha 2,6-sialyltransferase ST6Gal I
    NP_001003853.1
    XP_005161355.1
    XP_068071940.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003853.1 → NP_001003853.1  beta-galactoside alpha-2,6-sialyltransferase 1

      See identical proteins and their annotated locations for NP_001003853.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ744801
      UniProtKB/TrEMBL
      A0A8M2B8A7, F1QK50, Q6KB61
      Related
      ENSDARP00000065365.5, ENSDART00000065366.7
      Conserved Domains (1) summary
      pfam00777
      Location:249 → 454
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      31151110..31185301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161298.5 → XP_005161355.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B878, A0A8M2B8A7, F1QK50, F1QMH5
      Related
      ENSDARP00000106374.1, ENSDART00000126205.3
      Conserved Domains (1) summary
      pfam00777
      Location:260 → 465
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_068215839.1 → XP_068071940.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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