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    enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 562399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    enpp1provided by ZNC
    Official Full Name
    ectonucleotide pyrophosphatase/phosphodiesterase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-172
    See related
    Ensembl:ENSDARG00000005789 AllianceGenome:ZFIN:ZDB-GENE-040724-172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136238; si:ch211-142e24.2
    Summary
    Predicted to enable dinucleotide phosphatase activity and phosphodiesterase I activity. Acts upstream of or within phosphate ion homeostasis and regulation of bone mineralization. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface. Is expressed in cleithrum and opercle. Used to study arterial calcification of infancy and pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See enpp1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13403276..13521014)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13507257..13625034)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488715 Neighboring gene protein phosphatase 2, regulatory subunit B', alpha isoform Neighboring gene potassium channel, subfamily K, member 3a Neighboring gene synaptotagmin-like 3 Neighboring gene ezrin b Neighboring gene radial spoke head 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Reuter H, et al. Cells, 2022 Jan 20. PMID 35159152, Free PMC Article
    2. Generation and Validation of a Complete Knockout Model of abcc6a in Zebrafish. Van Gils M, et al. J Invest Dermatol, 2018 Nov. PMID 30030150
    3. Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction. Massé K, et al. Int J Dev Biol, 2010. PMID 19598106
    4. Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. Huitema LF, et al. Proc Natl Acad Sci U S A, 2012 Dec 26. PMID 23236130, Free PMC Article
    5. Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE). Apschner A, et al. Dis Model Mech, 2014 Jul. PMID 24906371, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. enpp1 can exert its function in tissues that are remote from its site of expression.
      Title: Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136238

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables dinucleotide phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphodiesterase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inorganic diphosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside triphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleotide pyrophosphatase/phosphodiesterase family member 1
    Names
    dgf
    NP_001025339.1
    XP_005160498.1
    XP_009292877.1
    XP_021324146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030168.1 → NP_001025339.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1

      Status: PROVISIONAL

      Source sequence(s)
      BX293547
      UniProtKB/TrEMBL
      A0A8M1N7G9
      Conserved Domains (5) summary
      smart00201
      Location:112 → 155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70 → 108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179 → 505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:177 → 545
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:642 → 860
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      13403276..13521014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160441.5 → XP_005160498.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

      See identical proteins and their annotated locations for XP_005160498.1

      UniProtKB/TrEMBL
      A0A8M2B797, B0JZL7, Q5RI82
      Related
      ENSDARP00000112341.3, ENSDART00000127350.4
      Conserved Domains (5) summary
      smart00201
      Location:112 → 155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70 → 108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179 → 505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:177 → 545
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:644 → 862
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

    2. XM_009294602.4 → XP_009292877.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B403
      Conserved Domains (4) summary
      pfam01033
      Location:70 → 108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:137 → 463
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cd16018
      Location:135 → 503
      Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
      cl00089
      Location:602 → 820
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.

    3. XM_021468471.2 → XP_021324146.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PPG3
      Conserved Domains (4) summary
      smart00201
      Location:112 → 155
      SO; Somatomedin B -like domains
      pfam01033
      Location:70 → 108
      Somatomedin_B; Somatomedin B domain
      pfam01663
      Location:179 → 505
      Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
      cl00089
      Location:644 → 740
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    Nucleotide Protein
    Heading Accession and Version

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