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    glud1b glutamate dehydrogenase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 373092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glud1bprovided by ZNC
    Official Full Name
    glutamate dehydrogenase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030828-1
    See related
    Ensembl:ENSDARG00000101074 AllianceGenome:ZFIN:ZDB-GENE-030828-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb719; glud1; zgc:55630; wu:fb16e02; wu:fb58f12; wu:fe37f03; wu:fj43f02; zgc:192851
    Summary
    Predicted to enable glutamate dehydrogenase (NAD+) activity. Predicted to be involved in glutamate catabolic process. Predicted to act upstream of or within amino acid metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; fin; mesoderm; muscle; and tail bud. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See glud1b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25845494..25881944)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25754134..25790584)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, epsilon a Neighboring gene endothelial PAS domain protein 1a Neighboring gene si:dkey-193p11.2 Neighboring gene synuclein, gamma b (breast cancer-specific protein 1)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Wang K, et al. Front Endocrinol (Lausanne), 2019. PMID 31231312, Free PMC Article
    2. Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes. Furukawa F, et al. Int J Biol Sci, 2015. PMID 25999794, Free PMC Article
    3. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity. Hagenaars A, et al. Chemosphere, 2013 May. PMID 23427857
    4. FOXN3 Regulates Hepatic Glucose Utilization. Karanth S, et al. Cell Rep, 2016 Jun 21. PMID 27292639, Free PMC Article
    5. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC192851

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate dehydrogenase 1b
    NP_955839.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199545.4 → NP_955839.2  glutamate dehydrogenase 1b

      See identical proteins and their annotated locations for NP_955839.2

      Status: VALIDATED

      Source sequence(s)
      CR931998, CU459179
      UniProtKB/TrEMBL
      A0A0R4IMI7, Q6P3L9, Q6PUR2
      Related
      ENSDARP00000135641.1, ENSDART00000170582.2
      Conserved Domains (3) summary
      cd01076
      Location:247 → 532
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      pfam00208
      Location:247 → 530
      ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
      pfam02812
      Location:97 → 224
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      25845494..25881944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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