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    pdhb pyruvate dehydrogenase E1 subunit beta [ Danio rerio (zebrafish) ]

    Gene ID: 406428, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pdhbprovided by ZNC
    Official Full Name
    pyruvate dehydrogenase E1 subunit betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2173
    See related
    Ensembl:ENSDARG00000021346 AllianceGenome:ZFIN:ZDB-GENE-040426-2173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64062; wu:fc76a05
    Summary
    Enables pyruvate dehydrogenase activity. Acts upstream of or within pigmentation. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in alar plate midbrain region; musculature system; optic tectum; optic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See pdhb in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10201865..10212502)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10172183..10182820)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1 Neighboring gene ribonuclease P/MRP 14 subunit Neighboring gene PX domain containing serine/threonine kinase Neighboring gene potassium channel tetramerization domain containing 6a Neighboring gene coiled-coil domain containing 71

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant. Maurer CM, et al. J Neurosci, 2010 Sep 8. PMID 20826660, Free PMC Article
    2. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Chen K, et al. J Proteomics, 2013 Jan 14. PMID 23117182
    3. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
    4. Zebrafish pigmentation mutations and the processes of neural crest development. Kelsh RN, et al. Development, 1996 Dec. PMID 9007256
    5. Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Qiu L, et al. Chemosphere, 2019 Oct. PMID 31154177

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Names
    DKEYP-87E7.2
    nir
    noir
    pyruvate dehydrogenase (lipoamide) beta
    pyruvate dehydrogenase E1 beta subunit
    NP_998319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213154.1 → NP_998319.1  pyruvate dehydrogenase E1 component subunit beta, mitochondrial

      See identical proteins and their annotated locations for NP_998319.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053233
      UniProtKB/TrEMBL
      A0A8M1PEP2, Q7T368
      Related
      ENSDARP00000002122.7, ENSDART00000006513.9
      Conserved Domains (3) summary
      cd07036
      Location:37 → 203
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PLN02683
      Location:8 → 356
      PLN02683; pyruvate dehydrogenase E1 component subunit beta
      pfam02780
      Location:226 → 349
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      10201865..10212502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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