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    ctsc cathepsin C [ Danio rerio (zebrafish) ]

    Gene ID: 368704, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ctscprovided by ZNC
    Official Full Name
    cathepsin Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030619-9
    See related
    Ensembl:ENSDARG00000101334 AllianceGenome:ZFIN:ZDB-GENE-030619-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb912; sb:cb146; wu:fb34g12; wu:fj58d01; ik:tdsubc_1h2
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ctsc in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (43604031..43625549, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43682954..43704472)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene actinin, alpha 4 Neighboring gene RAB38a, member RAS oncogene family Neighboring gene glutamate receptor, metabotropic 5b Neighboring gene tyrosinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker. Che R, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25181651
    2. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Tingaud-Sequeira A, et al. Gene, 2007 Jan 15. PMID 17027199
    3. An anti-inflammatory NOD-like receptor is required for microglia development. Shiau CE, et al. Cell Rep, 2013 Dec 12. PMID 24316075, Free PMC Article
    4. Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation. Hartig EI, et al. Biol Open, 2016 Aug 15. PMID 27444789, Free PMC Article
    5. Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. Wang Z, et al. BMC Genomics, 2010 Jun 22. PMID 20565988, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 1
    NP_999887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214722.1 → NP_999887.1  dipeptidyl peptidase 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC064286
      UniProtKB/TrEMBL
      Q6P2V1
      Related
      ENSDARP00000135284.2, ENSDART00000168589.2
      Conserved Domains (2) summary
      cd02621
      Location:224 → 452
      Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
      pfam08773
      Location:20 → 132
      CathepsinC_exc; Cathepsin C exclusion domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      43604031..43625549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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