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    frs2b fibroblast growth factor receptor substrate 2b [ Danio rerio (zebrafish) ]

    Gene ID: 436931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frs2bprovided by ZNC
    Official Full Name
    fibroblast growth factor receptor substrate 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-406
    See related
    Ensembl:ENSDARG00000037353 AllianceGenome:ZFIN:ZDB-GENE-040718-406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    frs2; zgc:91973; wu:fd21h10
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See frs2b in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (34727928..34740644, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (34222966..34235692, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489375 Neighboring gene DnaJ heat shock protein family (Hsp40) member A Neighboring gene nucleoporin 160 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 140 Neighboring gene adenosine deaminase tRNA specific 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor receptor substrate 2b
    Names
    fibroblast growth factor receptor substrate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002658.2 → NP_001002658.2  fibroblast growth factor receptor substrate 2b

      Status: VALIDATED

      Source sequence(s)
      BC076548, BX890570, CN502662, CU694365
      UniProtKB/TrEMBL
      A0A8M1N131, F1Q5H9, Q6DG07
      Related
      ENSDARP00000114775.2, ENSDART00000137665.3
      Conserved Domains (1) summary
      cd01202
      Location:33 → 124
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      34727928..34740644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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