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    slc38a2 solute carrier family 38 member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 566537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc38a2provided by ZNC
    Official Full Name
    solute carrier family 38 member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9659
    See related
    Ensembl:ENSDARG00000045886 AllianceGenome:ZFIN:ZDB-GENE-030131-9659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb115; sb:cb115; wu:fj34c01; si:ch211-132p20.4
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid import; neutral amino acid transport; and regulation of glutamate secretion, neurotransmission. Predicted to act upstream of or within sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in lens; notochord; and solid lens vesicle. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc38a2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1600300..1617897)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1728543..1768584)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38 member 4 Neighboring gene uncharacterized LOC110439353 Neighboring gene SR-related CTD-associated factor 11 Neighboring gene AT-rich interactive domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state. Lei HT, et al. Nat Struct Mol Biol, 2018 Jun. PMID 29872228, Free PMC Article
    2. QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. Breuer M, et al. PLoS One, 2019. PMID 30995231, Free PMC Article
    3. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540
    4. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acidic amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alanine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-proline import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-serine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in alanine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of glutamate secretion, neurotransmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid symporter 2
    Names
    amino acid transporter A2
    sodium-coupled neutral amino acid transporter 2
    solute carrier family 38, member 2 like
    system A amino acid transporter 2
    system A transporter 1
    system N amino acid transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045104.1 → NP_001038569.1  sodium-coupled neutral amino acid symporter 2

      See identical proteins and their annotated locations for NP_001038569.1

      Status: PROVISIONAL

      Source sequence(s)
      AL929171
      UniProtKB/Swiss-Prot
      Q5SPB1
      Related
      ENSDARP00000118404.2, ENSDART00000146779.3
      Conserved Domains (2) summary
      COG0814
      Location:70 → 479
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:72 → 488
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      1600300..1617897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SPB1.1 GenPept UniProtKB/Swiss-Prot:Q5SPB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.