U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ankhd1 ankyrin repeat and KH domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 563327, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ankhd1provided by ZNC
    Official Full Name
    ankyrin repeat and KH domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090421-1
    See related
    Ensembl:ENSDARG00000077860 AllianceGenome:ZFIN:ZDB-GENE-090421-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within heart contraction. Predicted to be active in cytoplasm. Orthologous to several human genes including ANKHD1 (ankyrin repeat and KH domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ankhd1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26408016..26483237, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26371321..26446769, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene zgc:110540 Neighboring gene transfer RNA serine (anticodon GCU)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Friedrichs F, et al. Genome Res, 2009 Mar. PMID 19064678, Free PMC Article
    2. Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Murphy PJ, et al. Cell, 2018 Feb 22. PMID 29456083
    3. Interaction of infectious spleen and kidney necrosis virus ORF119L with PINCH leads to dominant-negative inhibition of integrin-linked kinase and cardiovascular defects in zebrafish. Yuan JM, et al. J Virol, 2015 Jan. PMID 25355883, Free PMC Article
    4. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ankyrin repeat and KH domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199768.1 → NP_001186697.1  ankyrin repeat and KH domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      CR354383
      UniProtKB/TrEMBL
      A0A0R4IUB2, A0A8M1NVJ9
      Related
      ENSDARP00000138826.2, ENSDART00000169072.2
      Conserved Domains (7) summary
      smart00248
      Location:1048 → 1076
      ANK; ankyrin repeats
      cd00105
      Location:1709 → 1771
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:289 → 415
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:266 → 355
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:364 → 415
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:396 → 425
      ANK; ANK repeat [structural motif]
      cl09111
      Location:811 → 849
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      26408016..26483237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295484.4 → XP_009293759.1  ankyrin repeat and KH domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3ALL9
      Conserved Domains (7) summary
      smart00248
      Location:1059 → 1087
      ANK; ankyrin repeats
      cd00105
      Location:1720 → 1782
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:278 → 404
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:255 → 344
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:353 → 404
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:385 → 414
      ANK; ANK repeat [structural motif]
      cl09111
      Location:800 → 838
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. XM_009295483.4 → XP_009293758.1  ankyrin repeat and KH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AU09
      Conserved Domains (7) summary
      smart00248
      Location:1064 → 1092
      ANK; ankyrin repeats
      cd00105
      Location:1725 → 1787
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:283 → 409
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:260 → 349
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:358 → 409
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:390 → 419
      ANK; ANK repeat [structural motif]
      cl09111
      Location:805 → 843
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    3. XM_005161355.5 → XP_005161412.1  ankyrin repeat and KH domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8J4
      Conserved Domains (7) summary
      smart00248
      Location:1070 → 1098
      ANK; ankyrin repeats
      cd00105
      Location:1731 → 1793
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:289 → 415
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:266 → 355
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:364 → 415
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:396 → 425
      ANK; ANK repeat [structural motif]
      cl09111
      Location:811 → 849
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    4. XM_009295482.4 → XP_009293757.1  ankyrin repeat and KH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3AWZ5, E9QEX9
      Related
      ENSDARP00000121740.1, ENSDART00000147947.2
      Conserved Domains (7) summary
      smart00248
      Location:1075 → 1103
      ANK; ankyrin repeats
      cd00105
      Location:1736 → 1798
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:294 → 420
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:271 → 360
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:369 → 420
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:401 → 430
      ANK; ANK repeat [structural motif]
      cl09111
      Location:816 → 854
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.