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    rcc2 regulator of chromosome condensation 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rcc2provided by ZNC
    Official Full Name
    regulator of chromosome condensation 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2213
    See related
    Ensembl:ENSDARG00000011510 AllianceGenome:ZFIN:ZDB-GENE-040426-2213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    td-60; zgc:77115; wu:fb36a03
    Summary
    Predicted to enable small GTPase binding activity. Involved in neural crest cell migration. Predicted to be located in several cellular components, including chromosome, centromeric region; midbody; and spindle. Predicted to be active in membrane. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rcc2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (21521508..21535006, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (21594468..21608455, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207b Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10-like b Neighboring gene immunoglobin superfamily, member 21b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
    2. Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. Williamson RC, et al. J Cell Sci, 2014 Oct 1. PMID 25074804, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome passenger complex localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein RCC2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213176.1 → NP_998341.1  protein RCC2 homolog

      See identical proteins and their annotated locations for NP_998341.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066628
      UniProtKB/Swiss-Prot
      Q6NYE2
      Related
      ENSDARP00000004838.7, ENSDART00000010647.9
      Conserved Domains (2) summary
      pfam00415
      Location:141 → 190
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:121 → 154
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      21521508..21535006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162162.5 → XP_005162219.1  protein RCC2 homolog isoform X1

      See identical proteins and their annotated locations for XP_005162219.1

      UniProtKB/Swiss-Prot
      Q6NYE2
      Conserved Domains (2) summary
      pfam00415
      Location:141 → 190
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:121 → 154
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395145.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      38046..51544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYE2.1 GenPept UniProtKB/Swiss-Prot:Q6NYE2

    Gene LinkOut

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