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    shtn1 shootin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 407656, updated on 9-Dec-2024

    Summary

    Official Symbol
    shtn1provided by ZNC
    Official Full Name
    shootin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121127-1
    See related
    Ensembl:ENSDARG00000039697 AllianceGenome:ZFIN:ZDB-GENE-121127-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    shootin1; gb:bc139653; si:ch73-56p18.4
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within posterior lateral line neuromast primordium migration. Predicted to be located in several cellular components, including growth cone; lamellipodium; and perikaryon. Predicted to be part of microtubule associated complex. Predicted to be active in axonal growth cone; cell leading edge; and cytoplasm. Is expressed in nervous system and optic vesicle. Orthologous to human SHTN1 (shootin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See shtn1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21311401..21368712, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21291565..21348876, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 12, lysophospholipase Neighboring gene heat shock protein 12A Neighboring gene enolase 4 Neighboring gene ATPase, H+ transporting, lysosomal, V1 subunit B, member a Neighboring gene ventral anterior homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament bundle retrograde transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic actin-based contraction involved in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum polarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in netrin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within posterior lateral line neuromast primordium migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in substrate-dependent cell migration, cell extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cell leading edge IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of microtubule associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198761.1NP_001185690.1  shootin-1

      See identical proteins and their annotated locations for NP_001185690.1

      Status: VALIDATED

      Source sequence(s)
      BC115236
      UniProtKB/Swiss-Prot
      Q08C01, Q1RLX9, Q6P0R8
      Related
      ENSDARP00000058026.4, ENSDART00000058027.6
      Conserved Domains (2) summary
      TIGR01843
      Location:144286
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PRK13729
      Location:290345
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      21311401..21368712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467139.2XP_021322814.1  shootin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PE57
      Conserved Domains (1) summary
      cl25732
      Location:42303
      SMC_N; RecF/RecN/SMC N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394985.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      771..45800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)