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    tpd52l1 tpd52 like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tpd52l1provided by ZNC
    Official Full Name
    tpd52 like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-121
    See related
    Ensembl:ENSDARG00000042548 AllianceGenome:ZFIN:ZDB-GENE-050522-121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110003
    Summary
    Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of JNK cascade; and positive regulation of apoptotic signaling pathway. Predicted to be active in cytoplasm. Orthologous to human TPD52L1 (TPD52 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tpd52l1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (39691793..39735997, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (39789158..39833384, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488678 Neighboring gene hes-related family bHLH transcription factor with YRPW motif 2 Neighboring gene HD domain containing 2 Neighboring gene ring finger protein 217 Neighboring gene sodium/potassium transporting ATPase interacting 2 Neighboring gene uncharacterized LOC137488679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. Horzmann KA, et al. J Proteomics, 2018 Aug 30. PMID 30012420, Free PMC Article
    2. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110003

    General protein information

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    Preferred Names
    tumor protein D53
    Names
    tumor protein D52-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020734.1 → NP_001018570.1  tumor protein D53

      See identical proteins and their annotated locations for NP_001018570.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095121
      UniProtKB/TrEMBL
      B2GR41, F6NNE4, Q503Z0
      Related
      ENSDARP00000062401.4, ENSDART00000062402.7
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 173
      TPD52; Tumour protein D52 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      39691793..39735997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160821.5 → XP_005160878.1  tumor protein D53 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B7R8
      Conserved Domains (1) summary
      pfam04201
      Location:12 → 191
      TPD52; Tumour protein D52 family

    2. XM_009294889.4 → XP_009293164.1  tumor protein D53 isoform X3

      UniProtKB/TrEMBL
      A0A8M3ATF1
      Conserved Domains (1) summary
      pfam04201
      Location:26 → 205
      TPD52; Tumour protein D52 family

    3. XM_005160820.5 → XP_005160877.1  tumor protein D53 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B7S0
      Conserved Domains (1) summary
      pfam04201
      Location:34 → 195
      TPD52; Tumour protein D52 family

    4. XM_009294888.4 → XP_009293163.1  tumor protein D53 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AWF8
      Conserved Domains (1) summary
      pfam04201
      Location:34 → 208
      TPD52; Tumour protein D52 family

    5. XM_005160819.5 → XP_005160876.1  tumor protein D53 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B812
      Conserved Domains (1) summary
      pfam04201
      Location:34 → 213
      TPD52; Tumour protein D52 family
    Nucleotide Protein Strain
    Heading Accession and Version

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