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    dnajb1a DnaJ heat shock protein family (Hsp40) member B1a [ Danio rerio (zebrafish) ]

    Gene ID: 445177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnajb1aprovided by ZNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-90
    See related
    Ensembl:ENSDARG00000099383 AllianceGenome:ZFIN:ZDB-GENE-040801-90
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hspf1; dnajb1; zf-Hsp40; zgc:101068
    Summary
    Predicted to enable Hsp70 protein binding activity; transcription corepressor activity; and unfolded protein binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in cytosol. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dnajb1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (49150813..49163648, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (45005411..45018237, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 35-12 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene uncharacterized LOC137490149 Neighboring gene uncharacterized LOC137490150 Neighboring gene uncharacterized LOC137490774

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma. de Oliveira S, et al. Dis Model Mech, 2020 Apr 30. PMID 32102783, Free PMC Article
    2. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Khan SY, et al. Nat Commun, 2016 Apr 6. PMID 27218149, Free PMC Article
    3. A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Krall M, et al. Hum Genet, 2018 Apr. PMID 29713869, Free PMC Article
    4. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 1a
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 1
    DnaJ (Hsp40) homolog, subfamily B, member 1a
    heat shock 40kD protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003571.1 → NP_001003571.1  dnaJ homolog subfamily B member 1a

      See identical proteins and their annotated locations for NP_001003571.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077119
      UniProtKB/TrEMBL
      Q6DEJ4
      Related
      ENSDARP00000141952.1, ENSDART00000166146.2
      Conserved Domains (3) summary
      cd10747
      Location:157 → 321
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1 → 335
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:4 → 65
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      49150813..49163648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216646.1 → XP_068072747.1  dnaJ homolog subfamily B member 1a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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