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    mcm5 minichromosome maintenance complex component 5 [ Danio rerio (zebrafish) ]

    Gene ID: 286747, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mcm5provided by ZNC
    Official Full Name
    minichromosome maintenance complex component 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021209-1
    See related
    Ensembl:ENSDARG00000019507 AllianceGenome:ZFIN:ZDB-GENE-021209-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb34a06
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Acts upstream of or within several processes, including fibroblast growth factor receptor signaling pathway; hindbrain development; and negative regulation of apoptotic process. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; head; nervous system; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mcm5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25999477..26011440)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25868606..25880569)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885347 Neighboring gene glycine C-acetyltransferase Neighboring gene heme oxygenase 1a Neighboring gene FAD-dependent oxidoreductase domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Large-scale live imaging of adult neural stem cells in their endogenous niche. Dray N, et al. Development, 2015 Oct 15. PMID 26395477, Free PMC Article
    2. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358633
    3. Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon. März M, et al. Glia, 2010 May. PMID 20155821
    4. Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis. Ryu S, et al. Cell Cycle, 2006 Jun. PMID 16721065
    5. Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. Cerveny KL, et al. MicroPubl Biol, 2021. PMID 34723143, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. different tissues may employ distinct cellular programs in responding to the depletion of MCM5
      Title: Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell migration in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell proliferation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM5
    Names
    MCM5 minichromosome maintenance deficient 5
    NP_848523.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178436.3 → NP_848523.2  DNA replication licensing factor MCM5

      See identical proteins and their annotated locations for NP_848523.2

      Status: PROVISIONAL

      Source sequence(s)
      BC068359
      UniProtKB/TrEMBL
      Q6NV07
      Related
      ENSDARP00000018877.8, ENSDART00000024316.9
      Conserved Domains (3) summary
      cd00009
      Location:378 → 522
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00350
      Location:134 → 651
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:35 → 154
      MCM_N; MCM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25999477..26011440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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