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    ampd3b adenosine monophosphate deaminase 3b [ Danio rerio (zebrafish) ]

    Gene ID: 333997, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ampd3bprovided by ZNC
    Official Full Name
    adenosine monophosphate deaminase 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5929
    See related
    Ensembl:ENSDARG00000032469 AllianceGenome:ZFIN:ZDB-GENE-030131-5929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ampd3; fi25h10; zgc:55390; wu:fi25h10
    Summary
    Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to act upstream of or within purine ribonucleoside monophosphate biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including epidermis; hematopoietic system; periderm; peripheral olfactory organ; and ventral mesoderm. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ampd3b in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16762391..16796786, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (16773325..16806729, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene lymphatic vessel endothelial hyaluronic receptor 1b Neighboring gene ring finger protein 141 Neighboring gene uncharacterized LOC137488267 Neighboring gene adrenomedullin b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables AMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AMP deaminase 3b
    Names
    AMP deaminase 3
    adenosine monophosphate deaminase 3
    NP_956142.1
    XP_005159110.1
    XP_005159111.1
    XP_005159112.1
    XP_021323269.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199848.1 → NP_956142.1  AMP deaminase 3b

      See identical proteins and their annotated locations for NP_956142.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044154
      UniProtKB/TrEMBL
      Q803X5
      Related
      ENSDARP00000048721.6, ENSDART00000048722.8
      Conserved Domains (2) summary
      PLN03055
      Location:157 → 765
      PLN03055; AMP deaminase; Provisional
      cl00281
      Location:157 → 765
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      16762391..16796786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467594.2 → XP_021323269.1  AMP deaminase 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5I2, Q1LYD7
      Conserved Domains (1) summary
      cl00281
      Location:157 → 765
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. XM_005159053.5 → XP_005159110.1  AMP deaminase 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5I2, Q1LYD7
      Conserved Domains (1) summary
      cl00281
      Location:157 → 765
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. XM_005159055.5 → XP_005159112.1  AMP deaminase 3b isoform X3

      UniProtKB/TrEMBL
      A0A8M2B601
      Conserved Domains (2) summary
      PLN03055
      Location:137 → 745
      PLN03055; AMP deaminase; Provisional
      cl00281
      Location:137 → 745
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    4. XM_005159054.3 → XP_005159111.1  AMP deaminase 3b isoform X2

      UniProtKB/TrEMBL
      A0A8M2B614
      Conserved Domains (2) summary
      PLN03055
      Location:145 → 753
      PLN03055; AMP deaminase; Provisional
      cl00281
      Location:145 → 753
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395017.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      467578..499948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      9277..11566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011010699.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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