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    dus1l dihydrouridine synthase 1-like (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 322715, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dus1lprovided by ZNC
    Official Full Name
    dihydrouridine synthase 1-like (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1435
    See related
    Ensembl:ENSDARG00000089260 AllianceGenome:ZFIN:ZDB-GENE-030131-1435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63748; wu:fb71f06
    Summary
    Predicted to enable tRNA dihydrouridine synthase activity. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See dus1l in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36222799..36232656)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36093201..36103058)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 3a Neighboring gene casein kinase 1, delta a Neighboring gene G protein pathway suppressor 1 Neighboring gene Rac family small GTPase 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
    NP_955911.2
    XP_005164051.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199617.2 → NP_955911.2  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

      Status: VALIDATED

      Source sequence(s)
      BX897685, EH452764, EH524077, EH592252
      UniProtKB/TrEMBL
      A0A8M1PFK3, B0S7L0
      Related
      ENSDARP00000100228.2, ENSDART00000113105.3
      Conserved Domains (3) summary
      TIGR01623
      Location:420 → 455
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:35 → 267
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:37 → 315
      Dus; Dihydrouridine synthase (Dus)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      36222799..36232656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163994.4 → XP_005164051.1  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

      See identical proteins and their annotated locations for XP_005164051.1

      UniProtKB/TrEMBL
      Q6PD85
      Conserved Domains (3) summary
      TIGR01623
      Location:403 → 438
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:18 → 250
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:20 → 298
      Dus; Dihydrouridine synthase (Dus)
    Nucleotide Protein Strain
    Heading Accession and Version

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