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    uck2b uridine-cytidine kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 327057, updated on 9-Dec-2024

    Summary

    Official Symbol
    uck2bprovided by ZNC
    Official Full Name
    uridine-cytidine kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5265
    See related
    Ensembl:ENSDARG00000022213 AllianceGenome:ZFIN:ZDB-GENE-030131-5265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56174; wu:fa20g04
    Summary
    Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See uck2b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (6051916..6065416, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (6140034..6153534, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene sterol carrier protein 2a Neighboring gene CXXC motif containing zinc binding protein Neighboring gene aldehyde dehydrogenase 9 family, member A1b Neighboring gene zebrafish testis-expressed 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CTP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in UMP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uridine-cytidine kinase 2-B
    Names
    UCK 2-B
    cytidine monophosphokinase 2-B
    uridine monophosphokinase 2-B
    uridine-cytidine kinase 2
    NP_956058.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199764.2NP_956058.1  uridine-cytidine kinase 2-B

      See identical proteins and their annotated locations for NP_956058.1

      Status: VALIDATED

      Source sequence(s)
      AL954171, CB357915, EH512314
      UniProtKB/Swiss-Prot
      Q7ZV79
      UniProtKB/TrEMBL
      B2GQQ9
      Related
      ENSDARP00000033495.5, ENSDART00000037698.6
      Conserved Domains (2) summary
      COG0572
      Location:17232
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:24230
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      6051916..6065416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)