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    nme2b.1 NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30083, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nme2b.1provided by ZNC
    Official Full Name
    NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000210-32
    See related
    Ensembl:ENSDARG00000103791 AllianceGenome:ZFIN:ZDB-GENE-000210-32
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nme1; nme2; nm23b; NM23-B; ndpkz1; nme2b1; NDPK-Z1; NM23-Z1
    Summary
    Enables nucleoside diphosphate kinase activity. Acts upstream of or within GTP biosynthetic process and regulation of angiogenesis. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including digestive system; female organism; gonad; heart; and male organism. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See nme2b.1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (48117338..48120315)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48457539..48460510)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 Neighboring gene bloodthirsty-related gene family, member 30 Neighboring gene PR domain containing 1b, with ZNF domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Feng Y, et al. Arterioscler Thromb Vasc Biol, 2014 Oct. PMID 25147336
    2. The NM23 family in development. Bilitou A, et al. Mol Cell Biochem, 2009 Sep. PMID 19421718
    3. The NME gene family in zebrafish oogenesis and early development. Desvignes T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2011 Oct. PMID 21394481
    4. Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A. Ponnudurai RP, et al. J Proteomics, 2012 Jan 4. PMID 22079245
    5. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Hippe HJ, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805292, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions.
      Title: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
    2. Data show that NDPK B knockdown embryo results in a severe decrease in cardiac contractility.
      Title: The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleoside diphosphate kinase A
    Names
    non-metastatic cells 2, protein (NM23B) expressed in
    non-metastatic cells 2b.1, protein (NM23B) expressed in
    nucleoside diphosphate kinase-Z1
    NP_001349193.1
    NP_001349194.1
    NP_001349195.1
    NP_571001.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362264.1 → NP_001349193.1  nucleoside diphosphate kinase A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      CU694252, EH513618
      UniProtKB/TrEMBL
      A0A8M6Z292, Q9IAD3
      Conserved Domains (1) summary
      PTZ00093
      Location:6 → 163
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    2. NM_001362265.1 → NP_001349194.1  nucleoside diphosphate kinase A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      CU694252
      UniProtKB/TrEMBL
      Q9IAD3
      Conserved Domains (1) summary
      PTZ00093
      Location:6 → 152
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    3. NM_001362266.1 → NP_001349195.1  nucleoside diphosphate kinase A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      CU694252
      Conserved Domains (1) summary
      cl00335
      Location:1 → 84
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

    4. NM_130926.2 → NP_571001.2  nucleoside diphosphate kinase A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      CU694252
      UniProtKB/TrEMBL
      Q9IAD3
      Related
      ENSDARP00000136238.1, ENSDART00000160549.2
      Conserved Domains (1) summary
      PTZ00093
      Location:6 → 152
      PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      48117338..48120315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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