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    gria2a glutamate receptor, ionotropic, AMPA 2a [ Danio rerio (zebrafish) ]

    Gene ID: 170450, updated on 14-Nov-2024

    Summary

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    Official Symbol
    gria2aprovided by ZNC
    Official Full Name
    glutamate receptor, ionotropic, AMPA 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020125-3
    See related
    Ensembl:ENSDARG00000070173 AllianceGenome:ZFIN:ZDB-GENE-020125-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    glur2a; gria2.1; zfGRIA2[a]
    Summary
    Predicted to enable AMPA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; mechanosensory lateral line system development; and neural crest cell development. Predicted to be located in postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendritic spine and postsynaptic density membrane. Is expressed in nervous system. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See gria2a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (21331599..21409890, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (20638662..20716968, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 144a Neighboring gene mediator complex subunit 28 Neighboring gene uncharacterized LOC137490005 Neighboring gene glycine receptor, beta a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A real-time PCR method for the quantitative analysis of RNA editing at specific sites. Chen YC, et al. Anal Biochem, 2008 Apr 1. PMID 18252192
    2. Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model. Shrestha AP, et al. Int J Mol Sci, 2022 Aug 26. PMID 36077087, Free PMC Article
    3. Ultrastructural analysis of the glutamatergic system in the outer plexiform layer of zebrafish retina. Klooster J, et al. J Chem Neuroanat, 2009 Jul. PMID 19481010
    4. Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Moraes IB, et al. Front Biosci (Landmark Ed), 2023 Apr 14. PMID 37114543
    5. PKCgamma-induced trafficking of AMPA receptors in embryonic zebrafish depends on NSF and PICK1. Patten SA, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366675, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior lateral line development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 2a
    Names
    glutamate receptor, ionotropic, AMPA 2.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131894.1 → NP_571969.1  glutamate receptor 2a precursor

      See identical proteins and their annotated locations for NP_571969.1

      Status: PROVISIONAL

      Source sequence(s)
      AF525743
      UniProtKB/TrEMBL
      Q71E63
      Related
      ENSDARP00000093557.3, ENSDART00000102782.5
      Conserved Domains (4) summary
      cd13715
      Location:406 → 783
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:51 → 373
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:23 → 391
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      21331599..21409890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170897.4 → XP_005170954.1  glutamate receptor 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BI34
      Conserved Domains (4) summary
      cd13715
      Location:406 → 786
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:51 → 373
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:23 → 391
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    2. XM_005170896.3 → XP_005170953.1  glutamate receptor 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIL5
      Conserved Domains (4) summary
      cd13715
      Location:406 → 783
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:51 → 373
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:23 → 391
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    3. XM_005170898.4 → XP_005170955.1  glutamate receptor 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M2BI57
      Conserved Domains (4) summary
      cd13715
      Location:406 → 786
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:51 → 373
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:23 → 391
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394477.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      220314..296659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395372.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      213065..289388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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