mtor mechanistic target of rapamycin kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtorprovided by ZNC
Official Full Name: mechanistic target of rapamycin kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2974
See related: Ensembl:ENSDARG00000053196 AllianceGenome:ZFIN:ZDB-GENE-030131-2974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tor; frap1; wu:fc22h08
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including digestive tract development; positive regulation of myelination; and regulation of TOR signaling. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; male organism; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (46077609..46321889, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (46069803..46314010, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions.
Title: mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions.
The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation.
Title: The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation.
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.
Title: Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.
mTORC1 signaling governs biliary epithelial cells (BECs) driven liver regeneration by regulating the dedifferentiation of BECs and the proliferation of bipotential progenitor cells (BP-PCs)-derived hepatocytes and BECs.
Title: Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration.
In a retinal injury model, mTOR promotes retina regeneration by regulating the mRNA expression of key reprogramming factors.
Title: Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration.
mtor is identified as a candidate therapeutic target gene for BAG3 cardiomyopathy.
Title: Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS cells and supports that normal gene expression and translation requires ESCO2 function.
Title: Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome.
By inhibiting mTOR signaling via Fbxw7, the amount of myelination during development is reduced.
Title: Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.
up-regulated in model of hepatic steatosis
Title: Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
Title: Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

PMC299869P1 (e-PCR)
- UniSTS:272468

fi06g09.x1 (e-PCR)
- UniSTS:204440

fl05d08.x1 (e-PCR)
- UniSTS:201900

fc22h08.x1 (e-PCR)
- UniSTS:187824

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myelination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skin development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase mTOR

Names: FK506 binding protein 12-rapamycin associated protein 1; mechanistic target of rapamycin (serine/threonine kinase); target of rapamycin

NP_001070679.3

EC 2.7.1.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.