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    ptp4a3b protein tyrosine phosphatase 4A3b [ Danio rerio (zebrafish) ]

    Gene ID: 567691, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ptp4a3bprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase 4A3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2635
    See related
    Ensembl:ENSDARG00000054814 AllianceGenome:ZFIN:ZDB-GENE-030131-2635
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc14a08; si:ch211-251p5.5
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in endosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ptp4a3b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31453092..31505786, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31495165..31547878, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zgc:194210 Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene N-myc downstream regulated 1b Neighboring gene cellular communication network factor 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence. Lohani S, et al. J Cell Sci, 2022 Jan 15. PMID 34931244
    2. PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Johansson JA, et al. Dev Cell, 2020 Aug 10. PMID 32652076, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase type IVA 3
    Names
    protein tyrosine phosphatase type IVA, member 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      31453092..31505786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690988.10 → XP_696080.2  protein tyrosine phosphatase type IVA 3

      See identical proteins and their annotated locations for XP_696080.2

      UniProtKB/TrEMBL
      A0A8M2B4H8, E7FA22
      Related
      ENSDARP00000118752.1, ENSDART00000147616.3
      Conserved Domains (1) summary
      cl21483
      Location:11 → 160
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_005158177.5 → XP_005158234.1  protein tyrosine phosphatase type IVA 3

      See identical proteins and their annotated locations for XP_005158234.1

      UniProtKB/TrEMBL
      A0A8M2B4H8, E7FA22
      Conserved Domains (1) summary
      cl21483
      Location:11 → 160
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394962.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      319907..342720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472996.2 → XP_021328671.1  protein tyrosine phosphatase type IVA 3

      UniProtKB/TrEMBL
      A0A8M2B4H8, E7FA22
      Conserved Domains (1) summary
      cl21483
      Location:11 → 160
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein Strain
    Heading Accession and Version

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