map1lc3a microtubule-associated protein 1 light chain 3 alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map1lc3aprovided by ZNC
Official Full Name: microtubule-associated protein 1 light chain 3 alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2232
See related: Ensembl:ENSDARG00000033609 AllianceGenome:ZFIN:ZDB-GENE-040426-2232
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77094
Summary: Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be located in membrane. Predicted to be active in autophagosome membrane. Is expressed in forerunner cell group; nervous system; neural tube; skeletal muscle; and tail bud. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (26609110..26615608)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (26371494..26377992)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated proteins 1A/1B light chain 3A

Names: microtubule-associated protein 1-light chain 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214739.1 → NP_999904.1 microtubule-associated proteins 1A/1B light chain 3A

See identical proteins and their annotated locations for NP_999904.1

Status: PROVISIONAL

Source sequence(s)

BC067189

UniProtKB/TrEMBL

A1IIC2, Q6NX90

Related

ENSDARP00000042321.2, ENSDART00000042322.4

Conserved Domains (1) summary

cd17234
Location:4 → 120

Ubl_ATG8_MAP1LC3A; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3A (MAP1LC3A)