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    nqo1 NAD(P)H dehydrogenase, quinone 1 [ Danio rerio (zebrafish) ]

    Gene ID: 322506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nqo1provided by ZNC
    Official Full Name
    NAD(P)H dehydrogenase, quinone 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1226
    See related
    Ensembl:ENSDARG00000010250 AllianceGenome:ZFIN:ZDB-GENE-030131-1226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77191; wu:fb63c10
    Summary
    Predicted to enable NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including head; liver; neuromast; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including agranulocytosis; breast cancer (multiple); hematologic cancer (multiple); lung disease (multiple); and small cell carcinoma. Orthologous to several human genes including NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nqo1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56703251..56722320)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56401843..56420909)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 4b Neighboring gene beta-1,3-galactosyltransferase 2-like Neighboring gene kiaa0895l Neighboring gene casein kinase 2, alpha prime polypeptide a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos. Liu M, et al. Gene Expr Patterns, 2020 Dec. PMID 32889095
    2. The chemical defensome of five model teleost fish. Eide M, et al. Sci Rep, 2021 May 18. PMID 34006915, Free PMC Article
    3. The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio). Zhu X, et al. Nanotechnology, 2009 May 13. PMID 19420631
    4. Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Wu Y, et al. Dev Cell, 2023 Mar 13. PMID 36858041
    5. Relationship between Neuroprotective Effects and Structure of Procyanidins. Chen J, et al. Molecules, 2022 Apr 2. PMID 35408708, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
      Title: The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
    2. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.
      Title: Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)H dehydrogenase [quinone] 1
    NP_001191201.1
    NP_991105.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204272.2 → NP_001191201.1  NAD(P)H dehydrogenase [quinone] 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX255936
      UniProtKB/TrEMBL
      A0A2R8PW65, A0A8M1NYZ9
      Related
      ENSDARP00000145161.1, ENSDART00000184547.1
      Conserved Domains (1) summary
      pfam02525
      Location:7 → 226
      Flavodoxin_2; Flavodoxin-like fold

    2. NM_205542.3 → NP_991105.1  NAD(P)H dehydrogenase [quinone] 1 isoform 2

      See identical proteins and their annotated locations for NP_991105.1

      Status: VALIDATED

      Source sequence(s)
      BX255936
      UniProtKB/TrEMBL
      A0A8M1PJR2, Q6P0H2
      Related
      ENSDARP00000021150.6, ENSDART00000004964.8
      Conserved Domains (1) summary
      pfam02525
      Location:7 → 212
      Flavodoxin_2; Flavodoxin-like fold

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      56703251..56722320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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