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    tiparp TCDD-inducible poly(ADP-ribose) polymerase [ Danio rerio (zebrafish) ]

    Gene ID: 563506, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tiparpprovided by ZNC
    Official Full Name
    TCDD-inducible poly(ADP-ribose) polymeraseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031002-47
    See related
    Ensembl:ENSDARG00000061841 AllianceGenome:ZFIN:ZDB-GENE-031002-47
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc03g05; sb:cb841; wu:fc03g05; zgc:153056; si:dkey-33k14.4
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; forebrain neural keel; nervous system; neural plate; and neural tube. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See tiparp in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (34599315..34642086)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (34623291..34666062)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909167 Neighboring gene uncharacterized LOC137488311 Neighboring gene Leucine-, glutamate- and lysine-rich protein 1 Neighboring gene uncharacterized LOC137488312 Neighboring gene uncharacterized LOC101885893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Activator-blocker model of transcriptional regulation by pioneer-like factors. Riesle AJ, et al. Nat Commun, 2023 Sep 14. PMID 37709752, Free PMC Article
    2. Pluripotency factors determine gene expression repertoire at zygotic genome activation. Gao M, et al. Nat Commun, 2022 Feb 10. PMID 35145080, Free PMC Article
    3. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Feng L, et al. Dev Biol, 2010 Feb 1. PMID 19874812, Free PMC Article
    4. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153056

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase TIPARP
    NP_001038484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045019.3 → NP_001038484.1  protein mono-ADP-ribosyltransferase TIPARP

      Status: VALIDATED

      Source sequence(s)
      AI601719, CA472479, EB882039, EB973772, EE311950, EE316647, EH433035, EH459039
      UniProtKB/TrEMBL
      A0A0R4IVH6, A0A8M1N9V5
      Related
      ENSDARP00000138590.1, ENSDART00000159306.2
      Conserved Domains (3) summary
      cd01439
      Location:518 → 637
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:455 → 637
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam02825
      Location:327 → 390
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      34599315..34642086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395036.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      200153..234060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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