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    napab N-ethylmaleimide-sensitive factor attachment protein, alpha b [ Danio rerio (zebrafish) ]

    Gene ID: 327082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    napabprovided by ZNC
    Official Full Name
    N-ethylmaleimide-sensitive factor attachment protein, alpha bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5290
    See related
    Ensembl:ENSDARG00000020405 AllianceGenome:ZFIN:ZDB-GENE-030131-5290
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    napa; zgc:63906; wu:fa26c04
    Summary
    Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Predicted to be involved in several processes, including SNARE complex disassembly; glutamatergic synaptic transmission; and regulation of synaptic vesicle priming. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in head. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See napab in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44673996..44696810)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44680542..44703356)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene EH-domain containing 2b Neighboring gene uncharacterized LOC137488335 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2, like Neighboring gene myelin-associated glycoprotein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects. Nishiwaki Y, et al. Dev Cell, 2013 May 28. PMID 23725763
    2. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
    3. Transcriptome kinetics of arsenic-induced adaptive response in zebrafish liver. Lam SH, et al. Physiol Genomics, 2006 Nov 27. PMID 16882884
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SNARE complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-ethylmaleimide-sensitive factor attachment protein, alpha b
    Names
    N-ethylmaleimide sensitive fusion protein attachment protein alpha b
    alpha-snap1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199766.1 → NP_956060.1  N-ethylmaleimide-sensitive factor attachment protein, alpha b

      See identical proteins and their annotated locations for NP_956060.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054568
      UniProtKB/TrEMBL
      Q6TGX1, Q7T2F5
      Related
      ENSDARP00000009285.7, ENSDART00000018625.8
      Conserved Domains (3) summary
      sd00006
      Location:114 → 151
      TPR; TPR repeat [structural motif]
      cd15832
      Location:9 → 287
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
      pfam14938
      Location:9 → 288
      SNAP; Soluble NSF attachment protein, SNAP

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44673996..44696810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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