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    trim8b tripartite motif containing 8b [ Danio rerio (zebrafish) ]

    Gene ID: 559967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trim8bprovided by ZNC
    Official Full Name
    tripartite motif containing 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4325
    See related
    Ensembl:ENSDARG00000060729 AllianceGenome:ZFIN:ZDB-GENE-030131-4325
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    trim8; wu:fc90g07; si:ch211-208d15.5
    Summary
    Predicted to enable metal ion binding activity. Located in nucleus. Is expressed in central nervous system; retina; and trigeminal placode. Orthologous to human TRIM8 (tripartite motif containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See trim8b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (33919500..33935522)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (33818517..33834539)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gb Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene ADP ribosylation factor like GTPase 3b Neighboring gene sideroflexin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells. Maarifi G, et al. Sci Adv, 2019 Nov. PMID 31799391, Free PMC Article
    2. A fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish. Micale L, et al. PLoS One, 2012. PMID 23118857, Free PMC Article
    3. Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish. Boudinot P, et al. PLoS One, 2011. PMID 21789205, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM8b
    Names
    tripartite motif containing protein 8
    tripartite motif-containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044914.1 → NP_001038379.1  E3 ubiquitin-protein ligase TRIM8b

      See identical proteins and their annotated locations for NP_001038379.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928692
      UniProtKB/TrEMBL
      A0A8M1N9K8, Q1MTE4
      Related
      ENSDARP00000080323.4, ENSDART00000085888.6
      Conserved Domains (2) summary
      PHA02277
      Location:196 → 279
      PHA02277; hypothetical protein
      cl17238
      Location:15 → 55
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001142375.1 → NP_001135847.1  E3 ubiquitin-protein ligase TRIM8b

      See identical proteins and their annotated locations for NP_001135847.1

      Status: PROVISIONAL

      Source sequence(s)
      BC171664
      UniProtKB/TrEMBL
      B7ZVP9, F6NPR0, J9UDW6
      Conserved Domains (2) summary
      PHA02277
      Location:196 → 279
      PHA02277; hypothetical protein
      cl17238
      Location:15 → 55
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      33919500..33935522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394856.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      52876..68909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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