kidins220b kinase D-interacting substrate 220b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kidins220bprovided by ZNC
Official Full Name: kinase D-interacting substrate 220bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7824
See related: Ensembl:ENSDARG00000017338 AllianceGenome:ZFIN:ZDB-GENE-030131-7824
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj35h03; kidins220; zgc:63531; dZ119J18.2; wu:fj35h03
Summary: Enables PDZ domain binding activity. Predicted to be involved in nerve growth factor signaling pathway. Predicted to act upstream of or within nervous system development and phosphorylation. Predicted to be located in late endosome. Is expressed in hindbrain; motor neurons; and retina. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (29743893..29783649)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (29840983..29880803)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease.
Title: Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.
a novel partner of Kidins220/ARMS
Title: Kidins220/ARMS interacts with Pdzrn3, a protein containing multiple binding domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinase D-interacting substrate of 220 kDa B

Names: DKEYP-7F8.3; ankyrin repeat-rich membrane-spanning protein B; kinase D-interacting substrate of 220b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199982.2 → NP_956276.2 kinase D-interacting substrate of 220 kDa B

Status: PROVISIONAL

Source sequence(s)

BX293564

UniProtKB/Swiss-Prot

Q5TZ97, Q6P7Y1, Q7T163

UniProtKB/TrEMBL

A0A8M1PG79, Z4YJ74

Related

ENSDARP00000122680.1, ENSDART00000146366.3

Conserved Domains (5) summary

cd00204
Location:173 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07693
Location:449 → 960

KAP_NTPase; KAP family P-loop domain

pfam12796
Location:150 → 242

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:17 → 66

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

29743893..29783649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160637.5 → XP_005160694.1 kinase D-interacting substrate of 220 kDa B isoform X1

UniProtKB/Swiss-Prot

Q5TZ97, Q6P7Y1, Q7T163

UniProtKB/TrEMBL

A0A8M2B7H5

Conserved Domains (5) summary

cd00204
Location:173 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07693
Location:449 → 960

KAP_NTPase; KAP family P-loop domain

pfam12796
Location:150 → 242

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:17 → 66

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]
XM_005160638.5 → XP_005160695.1 kinase D-interacting substrate of 220 kDa B isoform X2

UniProtKB/Swiss-Prot

Q5TZ97, Q6P7Y1, Q7T163

UniProtKB/TrEMBL

A0A8M2B7H7

Conserved Domains (5) summary

cd00204
Location:173 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07693
Location:449 → 960

KAP_NTPase; KAP family P-loop domain

pfam12796
Location:150 → 242

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:17 → 66

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]
XM_005160639.5 → XP_005160696.1 kinase D-interacting substrate of 220 kDa B isoform X3

UniProtKB/Swiss-Prot

Q5TZ97, Q6P7Y1, Q7T163

UniProtKB/TrEMBL

A0A8M2B7R5

Conserved Domains (5) summary

cd00204
Location:173 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07693
Location:449 → 960

KAP_NTPase; KAP family P-loop domain

pfam12796
Location:150 → 242

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:17 → 66

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]
XM_005160640.5 → XP_005160697.1 kinase D-interacting substrate of 220 kDa B isoform X4

UniProtKB/Swiss-Prot

Q5TZ97, Q6P7Y1, Q7T163

UniProtKB/TrEMBL

A0A8M2B7I2

Conserved Domains (5) summary

cd00204
Location:173 → 298

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam07693
Location:449 → 960

KAP_NTPase; KAP family P-loop domain

pfam12796
Location:150 → 242

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:17 → 66

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:178 → 209

ANK; ANK repeat [structural motif]
XM_068215388.1 → XP_068071489.1 kinase D-interacting substrate of 220 kDa B isoform X1