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    akr1b1.2 aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553452, updated on 9-Dec-2024

    Summary

    Official Symbol
    akr1b1.2provided by ZNC
    Official Full Name
    aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-132
    See related
    Ensembl:ENSDARG00000045598 AllianceGenome:ZFIN:ZDB-GENE-041210-132
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153855; si:dkey-180p18.9
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See akr1b1.2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (14906610..14915293, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (14907855..14916538, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-14k9.3 Neighboring gene aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1 Neighboring gene PR domain containing 4 Neighboring gene proteasome 26S subunit, ATPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables all-trans-retinol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    uncharacterized protein LOC553452
    NP_001070715.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077247.1NP_001070715.1  uncharacterized protein LOC553452

      See identical proteins and their annotated locations for NP_001070715.1

      Status: PREDICTED

      Source sequence(s)
      BC124751
      UniProtKB/TrEMBL
      Q08BF3, Q1JPZ2
      Related
      ENSDARP00000067039.5, ENSDART00000067040.6
      Conserved Domains (2) summary
      COG0656
      Location:1306
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:8289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      14906610..14915293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)