otulina OTU deubiquitinase with linear linkage specificity a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otulinaprovided by ZNC
Official Full Name: OTU deubiquitinase with linear linkage specificity aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2157
See related: Ensembl:ENSDARG00000045422 AllianceGenome:ZFIN:ZDB-GENE-040426-2157
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fam105ba; zgc:64095; wu:fj43e01
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; lens; optic tectum; retina; and solid lens vesicle. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (10303123..10309934)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (10162737..10169548)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: OTU deubiquitinase with linear linkage specificity a

Names: family with sequence similarity 105, member B, a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.